Acetyl-L-carnitine is an amino acid that reduces ammonium levels in the blood and brain and may act as a neuroprotector.
In the human body, it is produced by the kidneys, provides energy, has antioxidant properties, and helps fight free radicals.
This natural biologically active substance, present in various organs and tissues, including the central nervous system, is involved in the metabolism of fatty acids and carbohydrates. The pharmacological effect is determined by the metabolic effects of L-carnitine and the acetyl group that makes up its composition.
Acetyl-L-carnitine is the biologically active form of L-carnitine, a key substance in the body's fat catabolism and energy production. Acetyl-L-carnitine is synthesized in brain tissue, liver and kidneys from L-carnitine with the participation of the enzyme carnitine acetyltransferase.
Acetylcarnitine delivers activated acetate directly to the mitochondrial matrix to form acetyl-CoA, which participates in the tricarboxylic acid cycle, i.e. acetylcarnitine is a substrate that triggers energy-dependent metabolic processes in mitochondria.
Due to the complete energy supply, when the tissues consume less oxygen, acetylcarnitine protects brain tissue from ischemia. Due to its structural similarity to acetylcholine, acetylcarnitine has a cholinomimetic effect. Acetylcarnitine increases the concentration of aspartic and glutamic acids, taurine in cells; with prolonged use, the density of M-methyl-B-aspartate receptors in the hippocampus, cortex and striatum increases, and their density does not decrease with aging.
Strengthens the effect of serotonin, protects brain cells from the neurotoxic effects of ammonia and glutamate. It has antiamnesic activity, improves learning processes, non-associative memory indicators, has a positive effect on memory functions in Alzheimer's disease, without causing a sedative and muscle relaxant effect. Stimulates the synthesis of proteins and phospholipids for membrane construction, improves regeneration processes.
Accelerates the regeneration of nerve cells in diabetic traumatic and endocrine peripheral nerve damage. It has a neuroprotective effect on neurons and their organelles (mitochondria), as well as a neurotrophic effect by modulating the activity of nerve growth factor. It has antioxidant and membrane-stabilizing effects. Slows down the aging process by increasing the transport of fatty acids into mitochondria.
Acetyl-L-carnitine performs many functions in the body:
- -Protects the brain, improves the quality of cognitive processes, and makes the mind clearer and more efficient.
- -Increases a person's physical capacity.
- -Removes toxins, free radicals and other harmful substances from the body.
- -Removes destructive fat cells, which reduces the risk of Alzheimer's and Parkinson's diseases.
- -Allows you to memorize information better, develops attention, and helps you highlight what is needed in a large flow of information.
- -Helps with memory loss.
- -It converts fat tissue into energy, but does not burn it.
- -Helps to lose weight and maintain weight loss if engaged in sports training.
- -Increases the speed of metabolic reactions and processes.
- -Strengthens blood vessels.
- -Supports the functioning of the nervous system.
- -Reduces fatigue, drowsiness, apathy.
- -Helps the body recover faster after sports training.
- -Improves immune function.
- -Protects a person from aging at the cellular level.
- -Improves strength during training.
In what cases is the supplement prescribed?
- -Acetyl-L-carnitine is prescribed in the following clinical cases:
- -Obsessive-compulsive disorder.
- -Memory disorder, partial or complete loss of memory.
- -Male reproductive system problems, including infertility.
- -Cataract or lens opacity.
- -Poor blood supply to certain areas of the brain.
- -Chronic alcoholism.
- -Recovery period after a stroke.
- -Common anxiety disorders.
- -Smoking abuse.
- -Recovery period after cerebral ischemic injury.
Acetyl-L-carnitine as a dietary supplement is popular in the sports industry and among ordinary people. The body tolerates this supplement well, it is quickly absorbed and has practically no contraindications to use.
The preparation has no strict contraindications, but in the following cases you should consult a specialist:
- -Chronic high blood pressure.
- -Regular sleep disturbances.
- -Hepatitis C.
- -Cirrhosis of the liver.
