What is Validol?

Validol was developed in Russia at the end of the 19th century. Its creator is considered to be chemist Alexander Valerianovich Gager. It was one of the first drugs intended to relieve the symptoms of angina pectoris. Developed during a period when menthol and valeric acid ester compounds were being intensively studied, Validol quickly became popular due to its effectiveness and ease of use. The drug became widely used in both Russia and other Eastern European countries as a remedy that could provide quick relief from heartache and nervous tension. Its popularity continued to grow due to its simple manufacturing process and affordable price. Although Validol is not universally recognized as a first-line drug in Western countries, it is still widely used in regions of the former Soviet Union and is considered an effective remedy for relieving heart and nervous system disorders. Validol is currently classified as a dietary supplement used to relieve symptoms of cardiovascular disorders, such as heart pain (angina pectoris) and symptoms caused by nervous tension. The main ingredients of Validol are menthol and a mixture of isovaleric acid methyl ester. Menthol is a natural product derived from peppermint oil and has a calming effect, while isovaleric acid methyl ester acts as an antispasmodic and mild vasodilator. Validol is often taken under the tongue (sublingually) to speed up the absorption and onset of action of its active ingredients. This medication is popular in some countries, especially Eastern Europe and Russia, as a means of reducing pain and relieving nervous tension. Main physical and chemical properties: solid regular round cylinders with flat upper and lower surfaces, beveled edges of the surfaces, capable of splitting, white or white with a yellowish tinge, with a characteristic menthol odor and cooling taste. On the surface of the tablets there may be gray inclusions and a powdery coating. Properties of Validol has a sedative effect on the central nervous system, and also causes a moderate reflex vasodilator (coronary lytic) effect, reflexively irritating the sensitive nerve ("cold") receptors of the oral mucosa. Stimulation of receptors is accompanied by induction of the release of endorphins, enkephalins, dynorphins and other opioid peptides, which play an important role in reducing pain, normalizing vascular permeability and regulating other important mechanisms of the cardiovascular and nervous systems. Under the action, physiologically active compounds are released - histamine, kinins, etc. When administered sublingually, Validol is absorbed from the oral mucosa. The therapeutic effect occurs within approximately 5 minutes. After absorption, the drug is biotransformed in the liver and excreted in the urine in the form of glucuronides. Indications Mild angina attacks, neuroses, hysteria, sea and air sickness (symptomatic therapy); headache associated with nitrate use. Contraindications Hypersensitivity to the components of the drug. Severe arterial hypotension, acute myocardial infarction. Interactions with medicinal products and other interactions Reduces the severity of headaches caused by nitrate use. Sedative and antihypertensive effects may be enhanced when used with other psychotropic and antihypertensive drugs, opioid analgesics, anesthetics, and alcohol. Application features In cases where pain in the heart area does not go away after taking the medication, it is necessary to consult a doctor to rule out acute coronary syndrome. Contains sugar, which should be taken into account by patients with diabetes. Instructions for use and dosages Keep the tablets in your mouth (under the tongue) until they dissolve completely. A single dose for adults is 1-2 tablets; daily dose is 2-4 tablets. If necessary, the daily dose can be increased. The maximum daily dose is 600 mg. Duration of use up to 7 days. Children There is no experience in the treatment of children. Possible adverse reactions Abdominal discomfort; hypersensitivity reactions including angioedema, urticaria, pruritus, rash. With prolonged use, mild nausea, tearing, dizziness, short-term arterial hypotension and drowsiness may sometimes occur, which quickly resolve on their own.